Question: What Type Of Disease Is CMT?

Does CMT affect your brain?

Unlike other neurological disorders, CMT usually isn’t life-threatening, and it almost never affects the brain.

It causes damage to the peripheral nerves — tracts of nerve cell fibers that connect the brain and spinal cord to muscles and sensory organs..

How many types of Charcot Marie Tooth disease are there?

It is possible to have two or more types of CMT, which happens when the person has mutations in two or more genes, each of which causes a form of the disease. CMT is a heterogenous genetic disease, meaning mutations in different genes can produce similar clinical symptoms.

Does CMT cause joint pain?

There are 2 types of pain associated with CMT: joint and muscle pain – caused by the stresses that CMT places on your body. neuropathic pain – caused by damage to your nerves (this is less common)

How bad can CMT get?

Complications of Charcot-Marie-Tooth disease vary in severity from person to person. Foot abnormalities and difficulty walking are usually the most serious problems. Muscles may get weaker, and you may injure areas of the body that experience decreased sensation.

At what age does CMT present?

The symptoms of CMT usually start to appear between the ages of 5 and 15, although they sometimes do not develop until well into middle age or later. CMT is a progressive condition.

Can CMT be passed from father to daughter?

This change is called a mutation. Some genetic mutations are hereditary, meaning they can be passed down from a parent to their child. CMT is caused by hereditary genetic mutations. But just because someone has CMT doesn’t mean they got it from one of their parents.

Does CMT cause back pain?

And, because joints often have more stress put on them because of weak muscles (weak ankles etc), then knees and hips have to do more work in people with CMT. Therefore, in my experience, arthritic pain and joint as well as back surgery are more frequent in patients with CMT.

Is CMT considered a disability?

Medically Qualifying Under A Disability Listing: CMT is a form of peripheral neuropathy, meaning it affects the nerves and muscles in the arms, legs, hands, and feet. The Social Security Administration (SSA) has a standard disability listing for this type of neurological disorder.

Is CMT a chronic condition?

CMT is a progressive condition, which means the symptoms gradually get worse over time. This means it may be difficult to spot symptoms in young children who have CMT.

Is CMT more common in males or females?

The condition affects an equal number of males and females. CMT hereditary neuropathy is the most common inherited neurological disorder affecting more than 250,000 Americans. Since this condition is frequently undiagnosed, misdiagnosed or diagnosed very late in life, the true number of affected persons may be higher.

Can CMT affect your eyes?

CMT Type 6 involves development of optic atrophy with loss of vision or blindness, muscle atrophy and weakness, loss of sensation, and balance and gait difficulties. Depending on the genetic cause of the CMT Type 6, there may be other symptoms including delayed learning.

Does CMT affect breathing?

How CMT affects breathing. The phrenic nerve, which controls the diaphragm muscle, can be affected by CMT. This is a rare complication, but it can be life-threatening when it occurs. Essentially, only half of the diaphragm moves when CMT patients breathe, meaning they are not getting a complete lungful of air.

What type of mutation is CMT?

Type 4 (CMT4) is distinguished from the other types by its pattern of inheritance; it can affect either the axons or the myelin. Type X Charcot-Marie-Tooth disease (CMTX) is caused by mutations in genes on the X chromosome, one of the two sex chromosomes.

Is Charcot Marie Tooth an autoimmune disease?

The phenotypic features encompasses neurological alterations similar to those observed in the axonal type 2 form of Charcot-Marie-Tooth disease (CMT2) and include autoimmune manifestations.

Can CMT make you tired?

Fatigue is a common symptom in CMT. A study, published in the Journal of Neurology in 2010 and based on questionnaire given patients and an age- and sex-matched control group, reported that fatigue levels were significantly higher in people with CMT. Fatigue in CMT can be due to a number of reasons.

Is CMT painful?

Paradoxically, despite sensory loss, some people with CMT experience pain — a combination of painful muscle cramps and neuropathic pain. This pain is not caused by an external trigger but by defective signals in sensory axons. Both types of pain usually can be alleviated with medication.

Does CMT affect memory?

The most common cause of CMT is the duplication of a region on the short arm of chromosome 17, which includes the gene PMP22. We report a thirty-seven-year-old man with CMT disease having sleep, memory and attention disorders characterized by brief retrograde amnesia at early age.

What is Charcot Marie Tooth type 2?

Charcot-Marie-Tooth disease type 2 (CMT2) is a type of CMT with genetic defects that disrupt the structure and function of the axons of the peripheral nerves. So, CMT2 often is referred to as “axonal CMT.” CMT2 is less common than CMT1 and accounts for about one-third of all dominant CMT cases.

Is CMT a type of muscular dystrophy?

No, CMT is not a type of muscular dystrophy. CMT is primarily a disease of the peripheral nerves, whereas muscular dystrophy is a group of diseases of the muscle itself. CMT causes weakness and impaired sensory perception because signals can’t get to and from the brain to muscle and skin, among other things.